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Original Research 


Micronuclei Frequency And White Blood Cell Indices Among Patients With Leukaemia And Multiple Myeloma Attending University Of Ilorin Teaching Hospital, Ilorin

Mutiat Aina Kareem, Luqman Olayinka Olatunbosun, Fatai Dayo Olalere, Abdulwaheed Adewale Ademosun, Gbadebo Maroof Oyeniyi, Abdulsamad Sanni Wamakko, Tesleemah Oluwakemi Davies-folorunso, Basiru Abubakar, Musa Abidemi Muhibi.


Abstract
Background: Leukaemia represents a heterogeneous group of blood cancers frequently linked to immune dysfunction and genomic instability.
Objectives: This study evaluated micronuclei frequency and white blood cell functional indices among leukaemic patients attending the University of Ilorin Teaching Hospital, Ilorin, Kwara State, Nigeria.
Materials and Methods: An analytical case–control design was employed involving consented 43 leukaemic subjects and age-matched healthy controls recruited. Venous blood samples were analyzed for White blood cell indices using an automated haematology analyzer, and Micronuclei Frequency using the cytokinesis-block method (CBMN).
Results: White blood cell functional indices (Relative lymphocyte count) were significantly elevated in patients across all types of cancer, AML (44.50 ± 1.29) compared to control (33.83 ± 6.34), ALL (35.75 ± 1.26) Control (33.83 ± 6.34), CLL (68.38 ± 1.77) Control (33.83 ± 6.34) and Multiple Myeloma (38.00 ± 14.77) Control (33.83 ± 6.34). Micronuclei frequency parameters and proliferation index were significantly higher in ALC and ANC relative to control in all participants (p < 0.01).
Conclusion: Leukaemia is associated with increased genomic instability and altered immune response. Micronuclei frequency and white blood cell functional indices may serve as useful adjuncts to leukaemic cells in evaluating disease progression and prognostic potential.

Key words: leukaemia’, ‘Micronuclei Frequency’, Multiple Myeloma ’, ‘White blood cell Indices’


 
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How to Cite this Article
Pubmed Style

Kareem MA, Olatunbosun LO, Olalere FD, Ademosun AA, Oyeniyi GM, Wamakko AS, Davies-folorunso TO, Abubakar B, Muhibi MA. Micronuclei Frequency And White Blood Cell Indices Among Patients With Leukaemia And Multiple Myeloma Attending University Of Ilorin Teaching Hospital, Ilorin. GMJ. 2026; 1(1): 29-38. doi:10.5455/GMJ.328810

Web Style

Kareem MA, Olatunbosun LO, Olalere FD, Ademosun AA, Oyeniyi GM, Wamakko AS, Davies-folorunso TO, Abubakar B, Muhibi MA. Micronuclei Frequency And White Blood Cell Indices Among Patients With Leukaemia And Multiple Myeloma Attending University Of Ilorin Teaching Hospital, Ilorin. https://www.gatemedjournal.org/?mno=328810 [Access: July 26, 2026]. doi:10.5455/GMJ.328810

AMA (American Medical Association) Style

Kareem MA, Olatunbosun LO, Olalere FD, Ademosun AA, Oyeniyi GM, Wamakko AS, Davies-folorunso TO, Abubakar B, Muhibi MA. Micronuclei Frequency And White Blood Cell Indices Among Patients With Leukaemia And Multiple Myeloma Attending University Of Ilorin Teaching Hospital, Ilorin. GMJ. 2026; 1(1): 29-38. doi:10.5455/GMJ.328810


Vancouver/ICMJE Style

Kareem MA, Olatunbosun LO, Olalere FD, Ademosun AA, Oyeniyi GM, Wamakko AS, Davies-folorunso TO, Abubakar B, Muhibi MA. Micronuclei Frequency And White Blood Cell Indices Among Patients With Leukaemia And Multiple Myeloma Attending University Of Ilorin Teaching Hospital, Ilorin. GMJ. (2026), [cited July 26, 2026]; 1(1): 29-38. doi:10.5455/GMJ.328810


Harvard Style

Kareem, M. A., Olatunbosun, . L. O., Olalere, . F. D., Ademosun, . A. A., Oyeniyi, . G. M., Wamakko, . A. S., Davies-folorunso, . T. O., Abubakar, . B. & Muhibi, . M. A. (2026) Micronuclei Frequency And White Blood Cell Indices Among Patients With Leukaemia And Multiple Myeloma Attending University Of Ilorin Teaching Hospital, Ilorin. GMJ, 1 (1), 29-38. doi:10.5455/GMJ.328810


Turabian Style

Kareem, Mutiat Aina, Luqman Olayinka Olatunbosun, Fatai Dayo Olalere, Abdulwaheed Adewale Ademosun, Gbadebo Maroof Oyeniyi, Abdulsamad Sanni Wamakko, Tesleemah Oluwakemi Davies-folorunso, Basiru Abubakar, and Musa Abidemi Muhibi. 2026. Micronuclei Frequency And White Blood Cell Indices Among Patients With Leukaemia And Multiple Myeloma Attending University Of Ilorin Teaching Hospital, Ilorin. Gateway Medical Journal, 1 (1), 29-38. doi:10.5455/GMJ.328810


Chicago Style

Kareem, Mutiat Aina, Luqman Olayinka Olatunbosun, Fatai Dayo Olalere, Abdulwaheed Adewale Ademosun, Gbadebo Maroof Oyeniyi, Abdulsamad Sanni Wamakko, Tesleemah Oluwakemi Davies-folorunso, Basiru Abubakar, and Musa Abidemi Muhibi. "Micronuclei Frequency And White Blood Cell Indices Among Patients With Leukaemia And Multiple Myeloma Attending University Of Ilorin Teaching Hospital, Ilorin." Gateway Medical Journal 1 (2026), 29-38. doi:10.5455/GMJ.328810


MLA (The Modern Language Association) Style

Kareem, Mutiat Aina, Luqman Olayinka Olatunbosun, Fatai Dayo Olalere, Abdulwaheed Adewale Ademosun, Gbadebo Maroof Oyeniyi, Abdulsamad Sanni Wamakko, Tesleemah Oluwakemi Davies-folorunso, Basiru Abubakar, and Musa Abidemi Muhibi. "Micronuclei Frequency And White Blood Cell Indices Among Patients With Leukaemia And Multiple Myeloma Attending University Of Ilorin Teaching Hospital, Ilorin." Gateway Medical Journal 1.1 (2026), 29-38. Print. doi:10.5455/GMJ.328810


APA (American Psychological Association) Style

Kareem, M. A., Olatunbosun, . L. O., Olalere, . F. D., Ademosun, . A. A., Oyeniyi, . G. M., Wamakko, . A. S., Davies-folorunso, . T. O., Abubakar, . B. & Muhibi, . M. A. (2026) Micronuclei Frequency And White Blood Cell Indices Among Patients With Leukaemia And Multiple Myeloma Attending University Of Ilorin Teaching Hospital, Ilorin. Gateway Medical Journal, 1 (1), 29-38. doi:10.5455/GMJ.328810


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